Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1508860 | 0.87 | SNCA (0.47) | SNCASLC6A2SLC6A4SLC6A3KCNH2 | |
| Bromide SCHEMBL30721146 | 0.84 | SNCA (0.51) | SNCAMAOBCYP3A4CYP2D6CYP1A2 | |
| Bromide SCHEMBL1508970 | 0.84 | SNCA (0.51) | SNCACYP2D6SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL8015170 | 0.84 | SNCA (0.51) | SNCAMAOBCYP3A4CYP2D6CYP1A2 | |
| Hydrochloric Acid SCHEMBL7338415 | 0.81 | SNCA (0.49) | SNCACYP2D6SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL25411424 | 0.80 | SNCA (0.47) | SNCASLC6A2SLC6A4SLC6A3HIF1A | |
| Bromide SCHEMBL3534572 | 0.80 | SNCA (0.47) | SNCACYP3A4CYP2D6KCNH2CYP1A2 | |
| Bromide SCHEMBL4171166 | 0.78 | SNCA (0.61) | SNCACYP3A4SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL5440664 | 0.78 | SNCA (0.45) | SNCADRD4 | |
| Bromide SCHEMBL4175917 | 0.77 | PNMT (0.50) | SNCACYP3A4SLC6A2SLC6A4GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298778-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROÝ2.5¨OCTANE RING STRUCTURE | Daiichi Sankyo Company, Limited (JP) | 2011-03-23 | — | — | EP | disclosed |