SCHEMBL15086697

SCHEMBL15086697

Cc1cc(F)c(C)c(C(=O)Oc2ccccc2)c1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NSD2 O96028 1/20 0.50
HPGD P15428 3/20 0.45
ALOX15 P16050 3/20 0.45
HSD17B10 Q99714 3/20 0.45
MAPT P10636 7/20 0.42
CYP3A4 P08684 2/20 0.42
LMNA P02545 2/20 0.42
TP53 P04637 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
CHRM1 P11229 1/20 0.42
TBXA2R P21731 1/20 0.42
SLC6A2 P23975 1/20 0.42
PDE4A P27815 1/20 0.42
ADRA1A P35348 1/20 0.42
KDR P35968 1/20 0.42
SLC6A3 Q01959 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
RAB9A P51151 2/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18602956 0.90 NSD2 (0.51) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL13083064 0.86 NSD2 (0.48) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL13064206 0.86 NSD2 (0.48) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL114127 0.86 NSD2 (0.48) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL13397787 0.85 NSD2 (0.47) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL19481430 0.83 NSD2 (0.41) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL113312 0.81 ALOX5 (0.46) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL14125011 0.80 HPGD (0.45) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL18602514 0.79 NSD2 (0.43) NSD2HPGDALOX15HSD17B10MAPT
SCHEMBL113401 0.79 HSD17B10 (0.51) NSD2HPGDALOX15HSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2323972-B1 C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS TETRAPHASE PHARMACEUTICALS INC (US) 2013-07-03 EP disclosed