Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15086743 | 0.97 | MAOB (0.60) | MAOBMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14484727 | 0.94 | MAOB (0.61) | MAOBMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15086772 | 0.91 | MAOB (0.50) | MAOBSMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL15086708 | 0.88 | MAOB (0.74) | MAOBSMN1; SMN2RAB9AMAPK1KMT2A | |
| SCHEMBL14484458 | 0.87 | MAOB (0.60) | MAOBMAPTSMN1; SMN2NPC1MAPK1 | |
| SCHEMBL15086775 | 0.86 | HPGD (0.52) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL14484788 | 0.85 | MAOB (0.56) | MAOBMAPTRAB9ANPC1MAPK1 | |
| SCHEMBL14484272 | 0.85 | MAOB (0.58) | MAOBMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15086705 | 0.84 | HPGD (0.43) | MAOBSMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL14484769 | 0.84 | MAOB (0.59) | MAOBMAPTSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-12-28 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | MAOB 3805/4885MAPT 4055/4885SMN1; SMN2 3843/4885 |
| US-20130172351-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | MAOB 3805/4885MAPT 4055/4885SMN1; SMN2 3843/4885 |
| US-20140296238-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | MAOB 3805/4885MAPT 4055/4885SMN1; SMN2 3843/4885 |
| US-20170071910-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | MAOB 3805/4885MAPT 4055/4885SMN1; SMN2 3843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.