Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15086754 | 0.95 | KMT2A (0.44) | KMT2AKDM4EALDH1A1HPGDCNR1 | |
| SCHEMBL15086742 | 0.92 | KMT2A (0.41) | KMT2AKDM4EALDH1A1HPGDCNR1 | |
| SCHEMBL15086753 | 0.87 | KMT2A (0.47) | KMT2AKDM4EALDH1A1HPGDCNR1 | |
| SCHEMBL15086792 | 0.87 | SCD (0.43) | KMT2AALDH1A1CNR1MCHR1 | |
| SCHEMBL15086749 | 0.86 | SCD (0.49) | KMT2AKDM4EALDH1A1HPGDCNR1 | |
| SCHEMBL15086769 | 0.85 | KMT2A (0.44) | KMT2AKDM4EALDH1A1HPGDCNR1 | |
| SCHEMBL15086756 | 0.84 | KMT2A (0.44) | KMT2AKDM4EALDH1A1HPGDPDE4A | |
| SCHEMBL15086751 | 0.84 | PDE4A (0.47) | KMT2AKDM4EALDH1A1HPGDCNR1 | |
| SCHEMBL15086752 | 0.79 | KMT2A (0.43) | KMT2AKDM4EALDH1A1HPGDCNR1 | |
| SCHEMBL15086799 | 0.79 | SCD (0.45) | KMT2AALDH1A1CNR1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-12-28 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | KMT2A 2373/4885KDM4E 1428/4885ALDH1A1 3510/4885 |
| US-20130172351-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | KMT2A 2373/4885KDM4E 1428/4885ALDH1A1 3510/4885 |
| US-20140296238-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | KMT2A 2373/4885KDM4E 1428/4885ALDH1A1 3510/4885 |
| US-20170071910-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | KMT2A 2373/4885KDM4E 1428/4885ALDH1A1 3510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.