Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 7/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15086965 | 0.87 | PIP4K2A (0.49) | PIP4K2APIK3CGAURKARPS6KB1GSK3A | |
| SCHEMBL15086952 | 0.84 | PIP4K2A (0.43) | PIP4K2APIK3CGAURKARPS6KB1GSK3A | |
| SCHEMBL14617851 | 0.81 | PIK3CG (0.40) | PIP4K2APIK3CGAURKARPS6KB1NPSR1 | |
| SCHEMBL14706378 | 0.77 | ABL1 (0.41) | PIP4K2APIK3CGAURKARPS6KB1NPSR1 | |
| SCHEMBL8344608 | 0.73 | MAPT (0.56) | GSK3B | |
| SCHEMBL1438403 | 0.73 | MAP4K4 (0.52) | AURKARPS6KB1NPSR1MAP4K4PRMT1 | |
| SCHEMBL15709569 | 0.73 | SRC (0.42) | PIP4K2APIK3CGNPSR1MAP4K4ABL1 | |
| SCHEMBL15087023 | 0.72 | GPR119 (0.52) | CYP3A4 | |
| SCHEMBL3891618 | 0.70 | ATR (0.37) | PIK3CGAURKARPS6KB1NPSR1MAP4K4 | |
| SCHEMBL15086956 | 0.70 | MAPT (0.52) | GSK3BNPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013102059-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE AND PYRROLO [2, 3-D] PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |