Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.45 |
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | DRD4 | P21917 | 6/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2757250 | 0.96 | CCR1 (0.48) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL8056158 | 0.94 | DRD2 (0.50) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL1610517 | 0.91 | CCR1 (0.52) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL30469416 | 0.82 | HTR2C (0.47) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL12093290 | 0.82 | HTR2C (0.47) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL12093289 | 0.82 | DRD2 (0.53) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL17888476 | 0.81 | DRD2 (0.53) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL171375 | 0.81 | DRD2 (0.44) | DRD2 | |
| SCHEMBL14240402 | 0.80 | MAP4K4 (0.51) | CCR1CCR8DRD2HTR1ADRD4 | |
| SCHEMBL23114442 | 0.79 | MAP4K4 (0.50) | DRD2HTR1ADRD4OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922385-A | Cgrp receptor antagonists | 伊莱利利公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107922406-A | CGRP receptor antagonist | 伊莱利利公司 | 2018-04-17 | — | — | CN | disclosed |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2013098373-A1 | NEW AZETIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-04 | — | — | WO | disclosed |
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PFIZER INC. | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | CCR1 3406/4885CCR8 3883/4885DRD2 205/4885 |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | CCR1 3406/4885CCR8 3883/4885DRD2 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.