Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15088395 | 1.00 | LRRK2 (0.37) | LRRK2MAPK1MAPK14JAK2JAK1 | |
| SCHEMBL15088431 | 1.00 | LRRK2 (0.37) | LRRK2MAPK1MAPK14JAK2JAK1 | |
| SCHEMBL15088466 | 0.71 | LRRK2 (0.43) | LRRK2MAPK1MAPK14JAK2JAK1 | |
| SCHEMBL10283145 | 0.70 | PIK3CA (0.36) | LRRK2MAPK1 | |
| SCHEMBL20840622 | 0.70 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL516176 | 0.70 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL20851935 | 0.70 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL8061460 | 0.70 | KCNH2 (0.36) | MAPK1 | |
| SCHEMBL16503391 | 0.69 | MAPK1 (0.37) | LRRK2MAPK1CSF1R | |
| SCHEMBL26980840 | 0.65 | PDE4D (0.39) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610258-A1 | Substituted piperidino dihydrothieno pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |