Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | CD38 | P28907 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283145 | 0.77 | PIK3CA (0.36) | MAPK1IRAK4PIK3CALRRK2NSD2 | |
| SCHEMBL20840622 | 0.72 | MAPK1 (0.35) | MAPK1PIK3CA | |
| SCHEMBL20851935 | 0.72 | MAPK1 (0.35) | MAPK1PIK3CA | |
| SCHEMBL516176 | 0.72 | MAPK1 (0.35) | MAPK1PIK3CA | |
| SCHEMBL8061460 | 0.72 | KCNH2 (0.36) | MAPK1PIK3CA | |
| SCHEMBL26980840 | 0.69 | PDE4D (0.39) | MAPK1PIK3CAEHMT2EHMT1 | |
| SCHEMBL10265576 | 0.69 | EML4 (0.36) | IRAK4EHMT2EHMT1 | |
| SCHEMBL15088431 | 0.69 | LRRK2 (0.37) | MAPK1LRRK2CSF1R | |
| SCHEMBL15088392 | 0.69 | LRRK2 (0.37) | MAPK1LRRK2CSF1R | |
| SCHEMBL15088395 | 0.69 | LRRK2 (0.37) | MAPK1LRRK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215093-B1 | NOVEL PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2011-12-14 | — | — | EP | disclosed |