Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9546475 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL9546482 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL28782106 | 0.88 | HTR2C (0.49) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL1509090 | 0.87 | HTR2C (0.53) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL13567880 | 0.87 | HTR2C (0.53) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL26197673 | 0.84 | HTR2C (0.60) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL3941416 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL3610882 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL1508494 | 0.82 | HTR2C (0.51) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL6121028 | 0.81 | HTR2C (0.63) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298778-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROÝ2.5¨OCTANE RING STRUCTURE | Daiichi Sankyo Company, Limited (JP) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298778-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROÝ2.5¨OCTANE RING STRUCTURE | Daiichi Sankyo Company, Limited (JP) | 2011-03-23 | — | — | EP | disclosed |