Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 6/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | CTSG | P08311 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200960 | 0.88 | ELANE (0.45) | SMN1; SMN2NPC1RAB9AHTR2CELANE | |
| SCHEMBL2207568 | 0.87 | HTR2C (0.46) | SMN1; SMN2NPC1RAB9AHTR2CELANE | |
| SCHEMBL9546482 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHTR2CAGTR2 | |
| SCHEMBL9546475 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHTR2CAGTR2 | |
| SCHEMBL1604782 | 0.82 | FKBP1A (0.41) | SMN1; SMN2NPC1RAB9AHTR2CELANE | |
| SCHEMBL13567880 | 0.82 | HTR2C (0.53) | SMN1; SMN2NPC1RAB9AHTR2CAGTR2 | |
| SCHEMBL1508927 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AHTR2CAGTR2 | |
| SCHEMBL1509090 | 0.82 | HTR2C (0.53) | SMN1; SMN2NPC1RAB9AHTR2CAGTR2 | |
| SCHEMBL15500345 | 0.81 | ELANE (0.44) | SMN1; SMN2NPC1RAB9AHTR2CELANE | |
| SCHEMBL1508494 | 0.81 | HTR2C (0.51) | SMN1; SMN2NPC1RAB9AHTR2CAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160352-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160352-A1 | ADENINE DERIVATIVES | HSP90AA1, TRAP1, HSP90AB1 | SMN1; SMN2 3585/4885NPC1 1183/4885RAB9A 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.