Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16556824 | 1.00 | TDP1 (0.50) | TDP1LMNAALDH1A1TSHRTHRB | |
| SCHEMBL827872 | 1.00 | TDP1 (0.50) | TDP1LMNAALDH1A1TSHRTHRB | |
| SCHEMBL283526 | 0.94 | — | — | |
| SCHEMBL19450283 | 0.87 | TSHR (0.44) | TDP1LMNAALDH1A1TSHR | |
| SCHEMBL19449972 | 0.87 | TSHR (0.44) | TDP1LMNAALDH1A1TSHR | |
| SCHEMBL19450212 | 0.87 | TSHR (0.44) | TDP1LMNAALDH1A1TSHR | |
| SCHEMBL12915076 | 0.87 | TSHR (0.44) | TDP1LMNAALDH1A1TSHR | |
| SCHEMBL14969788 | 0.87 | TSHR (0.44) | TDP1LMNAALDH1A1TSHR | |
| SCHEMBL12560763 | 0.87 | TSHR (0.44) | TDP1LMNAALDH1A1TSHR | |
| SCHEMBL1535121 | 0.84 | TSHR (0.47) | TDP1LMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150299703-A1 | IN VIVO GENE SILENCING BY CHEMICALLY MODIFIED AND STABLE siRNA | UNIVERSITY OF MASSACHUSETTS | 2015-10-22 | — | — | US | disclosed |
| US-9012623-B2 | In vivo gene silencing by chemically modified and stable siRNA | UNIVERSITY OF MASSACHUSETTS (US) | 2015-04-21 | — | — | US | disclosed |
| US-20130174286-A1 | In Vivo Gene Silencing By Chemically Modified and Stable siRNA | UNIVERSITY OF MASSACHUSETTS (US) | 2013-07-04 | — | — | US | disclosed |