Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 15/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371871 | 0.89 | MET (0.47) | KDREPHA2EPHB4MET | |
| SCHEMBL15090478 | 0.87 | MET (0.40) | KDRMETSRCTGFBR1AXL | |
| SCHEMBL13787632 | 0.85 | SRC (0.49) | KDREPHA2EPHB4METSRC | |
| SCHEMBL4402150 | 0.84 | MET (0.47) | KDREPHA2EPHB4MET | |
| SCHEMBL2927827 | 0.79 | MET (0.46) | KDRMET | |
| SCHEMBL5143520 | 0.77 | KDR (0.51) | KDREPHA2EPHB4SRCTGFBR1 | |
| SCHEMBL10245296 | 0.77 | KDR (0.55) | KDREPHA2EPHB4SRCTGFBR1 | |
| SCHEMBL371872 | 0.77 | MET (0.44) | KDRMET | |
| SCHEMBL372065 | 0.77 | KDR (0.56) | KDREPHA2EPHB4SRCTGFBR1 | |
| SCHEMBL372077 | 0.76 | KDR (0.49) | KDREPHA2EPHB4METERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612853-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-10 | — | — | EP | disclosed |