Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15597637 | 0.86 | PIK3CD (0.47) | KDM4EALDH1A1G6PDPARP1PIK3CG | |
| SCHEMBL12682789 | 0.84 | TAAR1 (0.43) | ALDH1A1GALR3NR2F2PIK3CGEGFR | |
| SCHEMBL15597642 | 0.83 | PIK3CD (0.47) | PARP1PIK3CGPIK3CD | |
| SCHEMBL15597654 | 0.82 | PIK3CD (0.41) | PIK3CGPIK3CD | |
| SCHEMBL4569299 | 0.80 | AURKA (0.39) | KDM4EPIK3CGEGFRPIK3CDLMNA | |
| SCHEMBL15597602 | 0.79 | PIK3CD (0.37) | PARP1PIK3CGPIK3CDTNKS2 | |
| SCHEMBL2506931 | 0.78 | PIK3CD (0.41) | GALR3NR2F2PIK3CGEGFRPIK3CD | |
| SCHEMBL4762934 | 0.78 | QTRT1 (0.41) | KDM4EALDH1A1MAPTG6PDPARP1 | |
| SCHEMBL356154 | 0.77 | PIK3CD (0.63) | PIK3CGPIK3CD | |
| SCHEMBL357282 | 0.77 | PIK3CD (0.63) | PIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612862-A2 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2013-07-10 | — | — | EP | claimed |
| EP-3943494-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3153514-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2017-04-12 | — | — | EP | disclosed |
| EP-2612862-A2 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2013-07-10 | — | — | EP | disclosed |