Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 7/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371976 | 0.91 | KDR (0.51) | METKDRTRPA1EGFRKIT | |
| SCHEMBL371931 | 0.91 | KDR (0.51) | METKDRTRPA1EGFRKIT | |
| SCHEMBL409483 | 0.86 | MET (0.62) | METKDRTRPA1EGFRKIT | |
| SCHEMBL15061166 | 0.83 | MET (0.49) | METKDRTRPA1EGFRKIT | |
| SCHEMBL371717 | 0.82 | KDR (0.52) | METKDREGFRKITFLT1 | |
| SCHEMBL15090667 | 0.82 | MET (0.73) | METKDREGFRKITFLT1 | |
| SCHEMBL372086 | 0.82 | MET (0.53) | METKDREGFRKITFLT1 | |
| SCHEMBL372133 | 0.81 | MET (0.57) | METKDREGFRKITFLT1 | |
| SCHEMBL371948 | 0.81 | MET (0.57) | METKDREGFRKITFLT1 | |
| SCHEMBL372147 | 0.79 | MET (0.52) | METKDRTRPA1EGFRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612853-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-10 | — | — | EP | disclosed |