Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29908838 | 1.00 | BRD4 (0.43) | BRD4NPSR1MAP4K4AURKAAURKB | |
| SCHEMBL15090993 | 0.90 | BRD4 (0.46) | BRD4NPSR1AURKALMNATOP2A | |
| SCHEMBL29908796 | 0.86 | NAMPT (0.49) | BRD4NCEH1NAMPTGAA | |
| SCHEMBL16239183 | 0.86 | NAMPT (0.49) | BRD4NCEH1NAMPTGAA | |
| SCHEMBL16239142 | 0.86 | KMT2A (0.43) | NPSR1MEN1KMT2ANPC1GAA | |
| SCHEMBL29908816 | 0.86 | KMT2A (0.43) | NPSR1MEN1KMT2ANPC1GAA | |
| SCHEMBL29908851 | 0.84 | NAMPT (0.47) | BRD4MAP4K4PRMT1NAMPTMAPKAPK2 | |
| SCHEMBL15090932 | 0.81 | PRMT1 (0.52) | BRD4NPSR1AURKAAURKBNCEH1 | |
| SCHEMBL29908819 | 0.81 | PRMT1 (0.52) | BRD4NPSR1AURKAAURKBNCEH1 | |
| SCHEMBL15091107 | 0.81 | PRMT1 (0.41) | BRD4NPSR1NCEH1PRMT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108863959-B | P2X4 receptor antagonists | 日本化学药品株式会社 | 2021-11-30 | — | — | CN | disclosed |
| CN-111333588-A | P2X4 receptor antagonists | 日本化学药品株式会社 | 2020-06-26 | — | — | CN | disclosed |
| CN-104066724-B | P2X4 receptor antagonists | 日本化学药品株式会社 | 2020-04-17 | — | — | CN | disclosed |
| EP-2631229-B1 | P2X4 RECEPTOR ANTAGONIST | NIPPON CHEMIPHAR CO (JP) | 2014-12-03 | — | — | EP | disclosed |
| US-8673915-B2 | P 2×4 receptor antagonist | NIPPON CHEMIPHAR CO., LTD. (JP) | 2014-03-18 | — | — | US | disclosed |
| EP-2631229-A1 | P2X4 RECEPTOR ANTAGONIST | Nippon Chemiphar Co., Ltd. (JP) | 2013-08-28 | — | — | EP | disclosed |
| US-20130178625-A1 | P 2 X 4 RECEPTOR ANTAGONIST | NIPPON CHEMIPHAR CO., LTD. (JP) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178625-A1 | P 2 X 4 RECEPTOR ANTAGONIST | P2RX4, P2RX2, P2RY4 | BRD4 373/4885NPSR1 36/4885MAP4K4 1919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.