Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509402 | 1.00 | ALK (0.37) | ALKNCF1PTGESSMN1; SMN2LMNA | |
| SCHEMBL1509405 | 0.99 | ALK (0.37) | ALKNCF1PTGESSMN1; SMN2LMNA | |
| SCHEMBL1509422 | 0.90 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAALDH1A1HTTPDK2 | |
| SCHEMBL1509440 | 0.89 | HDAC4 (0.41) | PTGESSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL1509420 | 0.88 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNAALDH1A1HTTPDK2 | |
| SCHEMBL1509457 | 0.85 | PDK2 (0.38) | SMN1; SMN2ALDH1A1PDK2HDAC4MAPT | |
| SCHEMBL1509398 | 0.83 | VHL (0.46) | PTGESSMN1; SMN2ALDH1A1PDK2HDAC4 | |
| SCHEMBL1436664 | 0.82 | MAPT (0.43) | PTGESSMN1; SMN2LMNAALDH1A1PDK2 | |
| SCHEMBL1437847 | 0.80 | PDK2 (0.41) | LMNAALDH1A1PDK2MAPTKDM4E | |
| SCHEMBL1509418 | 0.78 | THRA (0.36) | PTGESSMN1; SMN2ALDH1A1PDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026024-A2 | IMIDAZO [4,5-D] PYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | claimed |
| WO-2011026024-A2 | IMIDAZO [4,5-D] PYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | disclosed |