Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 13/20 | 0.57 |
| ▸ | CDK2 | P24941 | 13/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.57 |
| ▸ | PRKCB | P05771 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095846 | 0.81 | CCNA2 (0.66) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095338 | 0.81 | CCNA2 (0.66) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL13906188 | 0.80 | CDK2 (0.80) | CCNA2CDK2CCNA1PRKCBCDK1 | |
| SCHEMBL15095335 | 0.80 | CDK2 (0.55) | CCNA2CDK2CCNA1PRKCBCDK1 | |
| SCHEMBL15095339 | 0.79 | CCNA2 (0.66) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095332 | 0.78 | CCNA2 (0.80) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095334 | 0.77 | CCNA2 (0.60) | CCNA2CDK2CCNA1PRKCBCDK1 | |
| SCHEMBL15095344 | 0.76 | CCNA2 (0.57) | CCNA2CDK2CCNA1PRKCBCDK1 | |
| SCHEMBL15095342 | 0.76 | CCNA2 (0.70) | CCNA2CDK2CCNA1PRKCBCDK1 | |
| SCHEMBL15095341 | 0.74 | CDK2 (0.49) | CCNA2CDK2CCNA1PRKCBCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481585-B2 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-07-09 | — | — | US | disclosed |
| US-8481585-B2 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-07-09 | — | — | US | disclosed |