Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 11/20 | 0.66 |
| ▸ | CDK2 | P24941 | 11/20 | 0.66 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.66 |
| ▸ | CDK1 | P06493 | 1/20 | 0.66 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.66 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.66 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095332 | 0.90 | CCNA2 (0.80) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL13906188 | 0.88 | CDK2 (0.80) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095336 | 0.86 | CCNA2 (0.59) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095334 | 0.85 | CCNA2 (0.60) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095846 | 0.83 | CCNA2 (0.66) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095338 | 0.83 | CCNA2 (0.66) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095344 | 0.82 | CCNA2 (0.57) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095331 | 0.79 | CCNA2 (0.57) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL15095335 | 0.78 | CDK2 (0.55) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL3456901 | 0.77 | CDK2 (1.00) | CCNA2CDK2CCNA1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481585-B2 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-07-09 | — | — | US | disclosed |
| US-8481585-B2 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-07-09 | — | — | US | disclosed |