Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.56 |
| ▸ | PAK4 | O96013 | 4/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.56 |
| ▸ | CCNH | P51946 | 2/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | ULK1 | O75385 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.56 |
| ▸ | ERCC2 | P18074 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095333 | 0.78 | CDK2 (0.56) | CDK2CCNA2CCNA1PAK4CDK7 | |
| SCHEMBL25008205 | 0.76 | CCNA2 (0.66) | CDK2CCNA2CCNA1PAK4CDK1 | |
| SCHEMBL15095335 | 0.69 | CDK2 (0.55) | CDK2CCNA2CCNA1PAK4CDK1 | |
| SCHEMBL24669470 | 0.67 | CCNA2 (0.82) | CDK2CCNA2CCNA1PAK4CDK1 | |
| SCHEMBL15095342 | 0.66 | CCNA2 (0.70) | CDK2CCNA2CCNA1PAK4CDK1 | |
| SCHEMBL24513389 | 0.64 | CCNA2 (0.66) | CDK2CCNA2CCNA1PAK4CDK1 | |
| SCHEMBL15095338 | 0.63 | CCNA2 (0.66) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL15095332 | 0.62 | CCNA2 (0.80) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL13914860 | 0.62 | CDK2 (0.58) | CDK2CCNA2CCNA1PAK4CDK1 | |
| SCHEMBL15095846 | 0.62 | CCNA2 (0.66) | CDK2CCNA2CCNA1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481585-B2 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-07-09 | — | — | US | disclosed |
| US-8481585-B2 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-07-09 | — | — | US | disclosed |