Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 15/20 | 0.43 |
| ▸ | HTR2C | P28335 | 13/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064347 | 0.82 | KDM4C (0.51) | ALDH1A1MAPTHTR2AHTR2CKDM4C | |
| SCHEMBL19442038 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTHTR2AHTR2CKDM4C | |
| SCHEMBL364560 | 0.81 | MAPT (0.65) | ALDH1A1MAPTHTR2AHTR2CCOMT | |
| SCHEMBL13144356 | 0.79 | MAPT (0.50) | ALDH1A1MAPTCOMTIDO1 | |
| SCHEMBL2064569 | 0.78 | MAPT (0.49) | ALDH1A1MAPTHTR2AHTR2CKDM4C | |
| SCHEMBL323525 | 0.78 | MAPT (0.49) | ALDH1A1MAPTCOMTIDO1 | |
| SCHEMBL1095146 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPTHTR2AHTR2CCOMT | |
| SCHEMBL29573491 | 0.77 | HTR2A (0.73) | HTR2AHTR2C | |
| SCHEMBL1166246 | 0.77 | HTR2A (0.73) | HTR2AHTR2C | |
| SCHEMBL16705330 | 0.75 | MAPT (0.47) | ALDH1A1MAPTKDM4CCOMTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481535-B2 | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor | ARENA PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |