Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9965993 | 0.72 | KMT2A (0.46) | TSHRKMT2ASIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL15099393 | 0.72 | CHRM2 (0.41) | TSHRKMT2ASIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL16203621 | 0.65 | TSHR (0.53) | TSHRKMT2ACHRM1DRD2GRM5 | |
| SCHEMBL15203830 | 0.65 | TSHR (0.53) | TSHRKMT2ACHRM1DRD2GRM5 | |
| SCHEMBL15099412 | 0.65 | AGTR2 (0.47) | TSHRKMT2ASIGMAR1CHRM1KDM1A | |
| SCHEMBL11618119 | 0.64 | SLC6A2 (0.53) | TSHRKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27262808 | 0.64 | TSHR (0.56) | TSHRKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12932720 | 0.64 | CHRM1 (0.41) | TSHRSIGMAR1CHRM1KDM1AHTR2A | |
| SCHEMBL16356788 | 0.63 | AGTR2 (0.49) | TSHRSIGMAR1CHRM1KDM1AHTR2A | |
| SCHEMBL11275319 | 0.63 | CHRM1 (0.43) | TSHRKMT2ASIGMAR1CHRM1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013102242-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2013-07-11 | — | — | WO | disclosed |