Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15157049 | 1.00 | PPARA (0.54) | PPARASYKAPPKLK5PPARG | |
| SCHEMBL13933889 | 0.91 | KLK5 (0.57) | PPARASYKKLK5PPARGCTSS | |
| SCHEMBL15311383 | 0.91 | KLK5 (0.57) | PPARASYKKLK5PPARGCTSS | |
| SCHEMBL6388701 | 0.90 | KLK5 (0.57) | PPARASYKAPPKLK5CTSS | |
| SCHEMBL12214464 | 0.90 | KLK5 (0.57) | PPARASYKAPPKLK5CTSS | |
| SCHEMBL12873000 | 0.90 | KLK5 (0.57) | PPARASYKAPPKLK5CTSS | |
| SCHEMBL7679203 | 0.86 | PPARA (0.53) | PPARASYKAPPKLK5PPARG | |
| SCHEMBL20299921 | 0.86 | SYK (0.59) | PPARASYKAPPPPARGCTSS | |
| SCHEMBL20299917 | 0.86 | SYK (0.59) | PPARASYKAPPPPARGCTSS | |
| SCHEMBL3133276 | 0.86 | CTSS (0.56) | PPARASYKAPPKLK5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2809655-B1 | BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8927587-B2 | Chemical compounds | PFIZER LIMITED (GB) | 2015-01-06 | — | — | US | disclosed |
| EP-2809655-A1 | BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS | Pfizer Inc (US) | 2014-12-10 | — | — | EP | disclosed |
| US-20130274243-A1 | Chemical Compounds | PFIZER LTD (GB) | 2013-10-17 | — | — | US | disclosed |
| WO-2013114250-A1 | BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER INC. (US) | 2013-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274243-A1 | Chemical Compounds | SCN8A, SCN5A, KCNJ8 | PPARA 4206/4885SYK 1680/4885APP 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.