Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 6/20 | 0.41 |
| ▸ | FLT3 | P36888 | 6/20 | 0.41 |
| ▸ | ROS1 | P08922 | 4/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | STK4 | Q13043 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15452313 | 0.86 | SYK (0.55) | SYKJAK1JAK2JAK3 | |
| SCHEMBL15452311 | 0.76 | SYK (0.45) | SYKJAK1JAK2JAK3RET | |
| SCHEMBL2729936 | 0.73 | SYK (0.49) | SYKALKKDM4ECYP2C9CYP2C19 | |
| SCHEMBL10243655 | 0.73 | SYK (0.82) | SYKJAK1JAK2JAK3RET | |
| SCHEMBL15452276 | 0.72 | SYK (0.40) | SYKEML4ALK | |
| SCHEMBL15452303 | 0.67 | SYK (0.44) | SYKALKKDM4E | |
| SCHEMBL21955417 | 0.66 | KMT2A (0.54) | RAB9AKDM4ECYP2C9CYP2C19PTPN1 | |
| SCHEMBL2767991 | 0.65 | ME2 (0.58) | RAB9AKDM4ECYP2C9CYP2C19 | |
| SCHEMBL23544870 | 0.64 | KDM4E (0.56) | RAB9AKDM4ECYP2C9CYP2C19 | |
| SCHEMBL4383117 | 0.64 | JAK2 (0.73) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501944-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-08-06 | — | — | US | disclosed |