Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | GRK2 | P25098 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15210481 | 0.99 | GSK3B (0.63) | GSK3BDYRK1AKCNH2CCNA2CDK2 | |
| SCHEMBL23002843 | 0.88 | GSK3B (0.66) | GSK3BKCNH2CCNA2CDK2GRK2 | |
| SCHEMBL18934474 | 0.87 | GSK3B (0.57) | GSK3BDYRK1AKCNH2CCNA2CDK2 | |
| SCHEMBL15210880 | 0.84 | GSK3B (0.78) | GSK3BDYRK1ACDK2 | |
| SCHEMBL21550267 | 0.84 | GSK3B (0.66) | GSK3BKCNH2CCNA2CDK2GRK2 | |
| SCHEMBL6950333 | 0.83 | HTR4 (0.56) | GSK3BDYRK1AKCNH2CCNA2CDK2 | |
| SCHEMBL15210722 | 0.83 | GSK3B (0.77) | GSK3B | |
| Hydrochloric Acid SCHEMBL15210531 | 0.83 | GSK3B (0.76) | GSK3BDYRK1ACDK2 | |
| SCHEMBL23002847 | 0.83 | GSK3B (0.62) | GSK3BDYRK1AKCNH2 | |
| SCHEMBL16505614 | 0.81 | GSK3B (0.69) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817301-A1 | USE OF 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - S.p.A. (IT) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013124169-A1 | USE OF 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2013-08-29 | — | — | WO | disclosed |