SCHEMBL15211344

SCHEMBL15211344

CC(=O)Oc1csc2cc(OCc3ccc(C)nc3C)cc(Cl)c12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 5/20 0.42
PPARA Q07869 5/20 0.42
PPARG P37231 1/20 0.36
NMT1 P30419 1/20 0.35
MAPT P10636 4/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
ADK P55263 1/20 0.34
NPC1 O15118 4/20 0.33
RAB9A P51151 4/20 0.33
MBOAT4 Q96T53 1/20 0.33
SCD O00767 1/20 0.33
POLB P06746 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
S1PR4 O95977 1/20 0.32
IKBKB O14920 1/20 0.32
ALDH1A1 P00352 1/20 0.32
GAA P10253 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15211275 0.90 PPARD (0.39) PPARDPPARAPPARGMAPTADK
SCHEMBL15211634 0.89 PPARD (0.36) PPARDPPARAPPARGMAPTADK
SCHEMBL15211745 0.88 POLB (0.35) PPARDPPARAPPARGMAPTMAOB
SCHEMBL15211256 0.88 PPARD (0.35) PPARDPPARAPPARGMAOBADK
SCHEMBL17431435 0.88 PPARD (0.34) PPARDPPARAPPARGMAPTADK
SCHEMBL15211127 0.88 PPARD (0.47) PPARDPPARAPPARGMAPTADK
SCHEMBL15211568 0.86 PPARD (0.33) PPARDPPARAPPARGADKNPC1
SCHEMBL15211484 0.86 PPARD (0.33) PPARDPPARAPPARGADKPOLB
SCHEMBL15211438 0.85 PPARD (0.34) PPARDPPARAPPARGADK
SCHEMBL15211299 0.85 PPARD (0.39) PPARDPPARAPPARGMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2838891-A1 AROMATIC RING COMPOUND Takeda Pharmaceutical Company Limited (JP) 2015-02-25 EP disclosed
WO-2013125732-A1 AROMATIC RING COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-08-29 WO disclosed