Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211617 | 0.88 | PPARD (0.63) | POLBSLC26A4PPARDPPARANR4A2 | |
| SCHEMBL15220402 | 0.85 | HDAC8 (0.47) | POLBSLC26A4NR4A2MAPTALDH1A1 | |
| SCHEMBL17431376 | 0.85 | TDP1 (0.46) | POLBSLC26A4PPARDPPARANR4A2 | |
| SCHEMBL17431343 | 0.85 | TDP1 (0.46) | POLBSLC26A4PPARDPPARANR4A2 | |
| SCHEMBL15211684 | 0.84 | POLB (0.52) | POLBSLC26A4PPARDPPARANR4A2 | |
| SCHEMBL17444907 | 0.83 | HDAC8 (0.44) | POLBSLC26A4NR4A2MAPTALDH1A1 | |
| SCHEMBL15220395 | 0.82 | HDAC8 (0.46) | POLBSLC26A4NR4A2MAPTALDH1A1 | |
| SCHEMBL17431469 | 0.82 | MTNR1A (0.57) | POLBSLC26A4PPARDPPARANR4A2 | |
| SCHEMBL15211478 | 0.82 | PPARD (0.48) | POLBSLC26A4PPARDPPARANR4A2 | |
| SCHEMBL15211481 | 0.82 | PPARD (0.48) | POLBSLC26A4PPARDPPARANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238639-B2 | Aromatic ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-19 | — | — | US | disclosed |
| US-9238639-B2 | Aromatic ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-19 | — | — | US | disclosed |
| EP-2838891-A1 | AROMATIC RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013125732-A1 | AROMATIC RING COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-29 | — | — | WO | disclosed |