Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | BCL6 | P41182 | 4/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212485 | 0.81 | SYK (0.53) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL655687 | 0.77 | SYK (0.64) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL13007738 | 0.74 | SYK (0.49) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL656721 | 0.74 | SYK (0.56) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL15212360 | 0.74 | SYK (0.49) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL15212398 | 0.73 | SYK (0.51) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL4300310 | 0.72 | SYK (0.67) | SYKEGFR | |
| SCHEMBL656863 | 0.71 | SYK (0.43) | SYKBCL6 | |
| SCHEMBL2103987 | 0.71 | TRPV1 (0.51) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL2103481 | 0.70 | MAOB (0.51) | SYKJAK2EGFRLCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817306-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013126132-A1 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |