Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.67 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656243 | 0.91 | SYK (0.56) | SYKJAK1JAK3EGFR | |
| SCHEMBL17277978 | 0.87 | SYK (0.69) | SYKJAK1JAK3MAPTALDH1A1 | |
| SCHEMBL12212786 | 0.83 | SYK (0.70) | SYKJAK1JAK3MMP12EGFR | |
| SCHEMBL657010 | 0.83 | SYK (0.51) | SYKMAPTALDH1A1PIK3CDPIK3R1 | |
| SCHEMBL14607335 | 0.81 | SYK (0.67) | SYKJAK1JAK3 | |
| SCHEMBL13007738 | 0.81 | SYK (0.49) | SYKJAK1JAK3EGFR | |
| SCHEMBL656721 | 0.80 | SYK (0.56) | SYKJAK1JAK3PIK3CDEGFR | |
| SCHEMBL656578 | 0.80 | SYK (1.00) | SYKJAK1JAK3 | |
| SCHEMBL656760 | 0.80 | SYK (1.00) | SYKJAK1JAK3 | |
| SCHEMBL30009410 | 0.80 | SYK (1.00) | SYKJAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127642-A2 | USE OF LRRK2 INHIBITORS FOR NEURODEGENERATIVE DISEASES | CELLZOME LIMITED (GB) | 2009-10-22 | — | — | WO | disclosed |