Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.67 |
| ▸ | WEE1 | P30291 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | CCND1 | P24385 | 2/20 | 0.54 |
| ▸ | CCND2 | P30279 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 3/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18040870 | 0.90 | WEE1 (0.65) | CSF1RWEE1CYP3A4KCNH2EGFR | |
| SCHEMBL15207066 | 0.89 | CSF1R (0.61) | CSF1RWEE1CYP3A4KCNH2CDK4 | |
| SCHEMBL15212413 | 0.86 | CSF1R (0.68) | CSF1RWEE1CYP3A4KCNH2CDK4 | |
| SCHEMBL18040868 | 0.82 | WEE1 (0.54) | CSF1RWEE1CYP3A4BRD4JAK3 | |
| SCHEMBL15206425 | 0.81 | WEE1 (0.78) | CSF1RWEE1CYP3A4KCNH2CDK4 | |
| SCHEMBL15212246 | 0.80 | CSF1R (0.55) | CSF1RWEE1CYP3A4KCNH2CDK4 | |
| SCHEMBL3529028 | 0.80 | CSF1R (1.00) | CSF1RWEE1NTRK1KITSRC | |
| SCHEMBL15205965 | 0.79 | CDK4 (0.62) | CSF1RWEE1CYP3A4KCNH2CDK4 | |
| SCHEMBL15206928 | 0.79 | WEE1 (0.62) | CSF1RWEE1CYP3A4KCNH2EGFR | |
| SCHEMBL14633618 | 0.79 | JAK3 (0.61) | CSF1RWEE1CYP3A4KCNH2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817308-B1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC (US) | 2016-09-07 | — | — | EP | claimed |
| EP-2817308-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013126656-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC. (US) | 2013-08-29 | — | — | WO | disclosed |