Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | WEE1 | P30291 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCND1 | P24385 | 3/20 | 0.50 |
| ▸ | CCND2 | P30279 | 2/20 | 0.50 |
| ▸ | CCND3 | P30281 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15206531 | 0.87 | CSF1R (0.58) | CSF1RBRD4WEE1PLK1CDK4 | |
| SCHEMBL15212293 | 0.80 | CSF1R (0.67) | CSF1RBRD4WEE1JAK3CDK4 | |
| SCHEMBL14633664 | 0.78 | JAK3 (0.76) | CSF1RWEE1JAK3PLK1CDK4 | |
| SCHEMBL18040868 | 0.78 | WEE1 (0.54) | CSF1RBRD4WEE1JAK3PLK1 | |
| SCHEMBL15212413 | 0.78 | CSF1R (0.68) | CSF1RBRD4WEE1JAK3CDK4 | |
| SCHEMBL3814909 | 0.77 | EGFR (0.57) | BRD4JAK3CDK4CCND1CCND2 | |
| SCHEMBL18040870 | 0.76 | WEE1 (0.65) | CSF1RBRD4WEE1CYP3A4FGFR1 | |
| SCHEMBL17296027 | 0.76 | WEE1 (0.58) | WEE1PLK1CDK4CCND1CCND2 | |
| SCHEMBL30996122 | 0.75 | CDK4 (0.57) | CSF1RBRD4WEE1PLK1CDK4 | |
| SCHEMBL28228697 | 0.74 | LCK (0.60) | BRD4CDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817308-B1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC (US) | 2016-09-07 | — | — | EP | claimed |
| EP-2817308-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013126656-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC. (US) | 2013-08-29 | — | — | WO | disclosed |