SCHEMBL15212893

SCHEMBL15212893

NC(=O)c1c(C(F)(F)F)nn(-c2ccccc2)c1OC(F)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.37
BRAF P15056 1/20 0.37
KDR P35968 1/20 0.37
FPR1 P21462 1/20 0.37
RIPK2 O43353 4/20 0.36
PTGS2 P35354 4/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 2/20 0.34
ALDH1A1 P00352 2/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34
CYP2C19 P33261 1/20 0.34
KDM4E B2RXH2 1/20 0.34
PTGS1 P23219 2/20 0.34
SCN9A Q15858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15212892 0.84 SRC (0.38) SRCBRAFKDRFPR1RIPK2
SCHEMBL1765721 0.81 PDE4D (0.42) RIPK2ALDH1A1LMNAHPGDKDM4E
SCHEMBL10568444 0.77 SRC (0.56) SRCBRAFKDRRIPK2PTGS2
SCHEMBL16989247 0.70 HPGD (0.49) SRCBRAFKDRRIPK2PTGS2
SCHEMBL13861525 0.68 PARP1 (0.46) SMN1; SMN2POLBMAPTKMT2AALDH1A1
SCHEMBL31672711 0.68 KMT2A (0.38) FPR1PTGS2SMN1; SMN2POLBMAPT
SCHEMBL22976049 0.68 KDM4E (0.42) FPR1RIPK2PTGS2SMN1; SMN2POLB
SCHEMBL10572038 0.68 HPGD (0.67) SRCBRAFKDRFPR1RIPK2
SCHEMBL538098 0.68 CACNA1G (0.35) PTGS2SMN1; SMN2POLBMAPTKMT2A
SCHEMBL14482170 0.67 MEN1 (0.60) FPR1SMN1; SMN2POLBMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2911516-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE Bayer Cropscience LP (US) 2015-09-02 EP disclosed
EP-2816897-A1 USE OF SUCCINATE DEHYDROGENASE INHIBITORS (SDHIS) FOR CONTROLLING WOOD DISEASES IN GRAPE Bayer CropScience AG (DE) 2014-12-31 EP disclosed
WO-2014066878-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE LP (US) 2014-05-01 WO disclosed
WO-2013124275-A1 USE OF SUCCINATE DEHYDROGENASE INHIBITORS (SDHIS) FOR CONTROLLING WOOD DISEASES IN GRAPE. BAYER CROPSCIENCE AG (DE) 2013-08-29 WO disclosed