⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3330004 | 0.97 | MEN1 (0.31) | — | |
| SCHEMBL31136658 | 0.94 | — | — | |
| SCHEMBL31136836 | 0.88 | — | — | |
| SCHEMBL28709410 | 0.79 | — | — | |
| SCHEMBL3334026 | 0.75 | GAA (0.34) | — | |
| SCHEMBL4045630 | 0.72 | — | — | |
| SCHEMBL31396331 | 0.72 | — | — | |
| SCHEMBL3331880 | 0.71 | HRH3 (0.33) | — | |
| SCHEMBL666848 | 0.70 | — | — | |
| SCHEMBL8387047 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257076-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-08-14 | — | — | US | disclosed |
| WO-2013120980-A1 | TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-22 | — | — | WO | disclosed |