Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | BCL2 | P10415 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 2/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22002815 | 0.86 | KMT2A (0.59) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28809795 | 0.84 | MAPT (0.56) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1122739 | 0.82 | BCL2 (0.64) | KMT2AALDH1A1BCL2MCL1MAPT | |
| SCHEMBL11576250 | 0.81 | NPC1 (0.51) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8338080 | 0.81 | HTT (0.56) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11576784 | 0.81 | NPC1 (0.55) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9851196 | 0.81 | KMT2A (0.70) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28518456 | 0.81 | LIG1 (0.61) | KMT2AALDH1A1BCL2MCL1CES2 | |
| SCHEMBL28926999 | 0.80 | CA1 (0.57) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28926996 | 0.80 | CA1 (0.57) | KMT2ANPC1NPSR1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518999-B2 | Modulators of TNF-αsignaling | GENZYME CORPORATION (US) | 2013-08-27 | — | — | US | disclosed |