Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11576250 | 0.85 | NPC1 (0.51) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL28811495 | 0.85 | ALDH1A1 (0.56) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL15214042 | 0.81 | KMT2A (0.64) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL4247963 | 0.79 | LMNA (0.52) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL30374771 | 0.78 | HPGD (0.71) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL93177 | 0.78 | HPGD (0.71) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL8340088 | 0.78 | NPC1 (0.61) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL228916 | 0.78 | LMNA (0.81) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL29415029 | 0.78 | LMNA (0.81) | HTTALDH1A1LMNACYP1A2PGR | |
| SCHEMBL8340505 | 0.78 | NPC1 (0.56) | HTTALDH1A1LMNACYP1A2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897918-A1 | Benzothiophene derivatives and their use as pharmaceutically active agents | ELI LILLY AND COMPANY (US) | 1999-02-24 | — | — | EP | disclosed |
| WO-1999007694-A1 | COMPOUNDS AND USES THEREOF | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |