Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 13/20 | 0.54 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.52 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.52 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214058 | 0.90 | IL2 (0.50) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL5555303 | 0.88 | IL2 (0.53) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL5556022 | 0.88 | STIM1 (0.53) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL8257494 | 0.85 | IL2 (0.66) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL8257121 | 0.85 | STIM1 (0.61) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL15214057 | 0.83 | IL2 (0.54) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL5550551 | 0.83 | IL2 (0.54) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL5550920 | 0.83 | IL2 (0.54) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL15395771 | 0.82 | IL2 (0.65) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL15395892 | 0.81 | STIM1 (0.63) | IL2STIM1ORAI1ORAI2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518950-B2 | pyrazinyl, pyrimidinyl and pyridazinyl derivatives such asN-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-2,6-difluoro-benzamide, used as immunosuppressants for the treatmet or prevent inflammatory and immune disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2013-08-27 | — | — | US | disclosed |