Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.61 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.61 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.61 |
| ▸ | IL2 | P60568 | 11/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556022 | 0.94 | STIM1 (0.53) | STIM1ORAI1ORAI2IL2POLB | |
| SCHEMBL8258488 | 0.87 | IL2 (0.47) | STIM1ORAI1ORAI2IL2RAB9A | |
| SCHEMBL5550482 | 0.85 | IL2 (0.47) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL15214056 | 0.85 | IL2 (0.54) | STIM1ORAI1ORAI2IL2POLB | |
| SCHEMBL8263132 | 0.83 | IL2 (0.47) | STIM1ORAI1ORAI2IL2RAB9A | |
| SCHEMBL8258539 | 0.83 | STIM1 (0.53) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL5555303 | 0.82 | IL2 (0.53) | STIM1ORAI1ORAI2IL2POLB | |
| SCHEMBL5550479 | 0.80 | IL2 (0.51) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL5554305 | 0.79 | IL2 (0.44) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL29216896 | 0.78 | STIM1 (0.69) | STIM1ORAI1ORAI2IL2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |