Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.60 |
| ▸ | PGR | P06401 | 3/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214220 | 0.94 | HIF1A (0.60) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12554539 | 0.93 | LMNA (0.57) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12554528 | 0.90 | LMNA (0.55) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL13659974 | 0.89 | HIF1A (0.58) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12586124 | 0.89 | HIF1A (0.58) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12554537 | 0.89 | LMNA (0.57) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL13655924 | 0.87 | LMNA (0.57) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL1977212 | 0.87 | LMNA (0.57) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12586265 | 0.86 | HIF1A (0.60) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12586458 | 0.85 | HIF1A (0.58) | HIF1ALMNACYP3A4NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518920-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2013-08-27 | — | — | US | disclosed |