Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.38 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16123784 | 0.86 | SLC29A1 (0.46) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15214759 | 0.86 | CYP51A1 (0.37) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL13394054 | 0.85 | SLC29A1 (0.47) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL13394148 | 0.85 | SLC29A1 (0.47) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15214750 | 0.85 | ADORA2A (0.41) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL13394123 | 0.85 | HDAC6 (0.43) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15214751 | 0.85 | PDE10A (0.51) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL13394062 | 0.83 | PDE10A (0.52) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15214136 | 0.83 | PDE10A (0.41) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL12112171 | 0.83 | MEN1 (0.47) | ADORA2ASLC29A1HDAC6FGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518901-B2 | Fused diimidazodiazepine compounds and methods of use and manufacture thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-08-27 | — | — | US | disclosed |