Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 12/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112215 | 0.93 | HDAC6 (0.47) | HDAC6FGFR1FGFR4HDAC1YTHDC1 | |
| SCHEMBL12112216 | 0.87 | FGFR1 (0.43) | HDAC6FGFR1FGFR4YTHDC1PDE4A | |
| SCHEMBL12112160 | 0.82 | PDE10A (0.48) | HDAC6FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL15214761 | 0.82 | FGFR1 (0.46) | HDAC6FGFR1FGFR4HDAC1PDE4A | |
| SCHEMBL13394148 | 0.81 | SLC29A1 (0.47) | HDAC6FGFR1FGFR4 | |
| SCHEMBL13394123 | 0.81 | HDAC6 (0.43) | HDAC6FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL16123784 | 0.80 | SLC29A1 (0.46) | HDAC6FGFR1FGFR4P2RX7 | |
| SCHEMBL12112177 | 0.79 | PDE10A (0.44) | HDAC6FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL12112214 | 0.79 | PDE10A (0.44) | HDAC6FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL15214751 | 0.79 | PDE10A (0.51) | HDAC6FGFR1FGFR4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518901-B2 | Fused diimidazodiazepine compounds and methods of use and manufacture thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-08-27 | — | — | US | disclosed |