Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168183 | 0.86 | NOS2 (0.53) | HTTMAPK1NPC1KDM4EPKM | |
| SCHEMBL2309144 | 0.85 | MAPK1 (0.61) | HTTMAPK1NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7167676 | 0.84 | NOS2 (0.52) | HTTMAPK1NPC1KDM4EPKM | |
| SCHEMBL9995179 | 0.83 | NPC1 (0.52) | HTTMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7294918 | 0.83 | NOS2 (0.50) | L3MBTL1HTTMAPK1NPC1RAB9A | |
| SCHEMBL2494868 | 0.83 | ESR2 (0.62) | L3MBTL1HTTMAPK1NPC1KDM4E | |
| SCHEMBL5945572 | 0.83 | ESR1 (0.54) | HTTMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7760076 | 0.82 | MAPK1 (0.79) | L3MBTL1HTTMAPK1NPC1KDM4E | |
| SCHEMBL23652406 | 0.82 | KDM4E (0.55) | L3MBTL1HTTMAPK1NPC1KDM4E | |
| SCHEMBL10176264 | 0.82 | ADORA2A (0.49) | HTTMAPK1SMN1; SMN2NOD1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |