Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722062 | 0.93 | SMN1; SMN2 (0.43) | HSD11B1HRH3PDE5APDE4APDE1A | |
| SCHEMBL210732 | 0.92 | HTT (0.46) | HSD11B1HRH3PDE5APDE4APDE1A | |
| SCHEMBL210028 | 0.91 | HSD11B1 (0.40) | HSD11B1HRH3PDE5APDE4APDE1A | |
| Hydrochloric Acid SCHEMBL209222 | 0.91 | HTT (0.47) | HSD11B1HRH3PDE5APDE4APDE1A | |
| SCHEMBL12576591 | 0.91 | HSD11B1 (0.40) | HSD11B1HRH3PDE5APDE4APDE1A | |
| SCHEMBL211080 | 0.91 | PDE5A (0.48) | HSD11B1HRH3PDE5APDE4APDE1A | |
| Hydrochloric Acid SCHEMBL207291 | 0.90 | PDE5A (0.47) | HSD11B1HRH3PDE5APDE4APDE1A | |
| SCHEMBL209326 | 0.89 | HSD11B1 (0.43) | HSD11B1HRH3PDE5APDE4APDE1A | |
| SCHEMBL208807 | 0.89 | HSD11B1 (0.46) | HSD11B1HRH3ALDH1A1KMT2A | |
| SCHEMBL210606 | 0.89 | HSD11B1 (0.46) | HSD11B1HRH3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-B1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2013-08-28 | — | — | EP | disclosed |