Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 2/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209858 | 0.92 | HRH3 (0.44) | KMT2AHPGDALDH1A1HRH3L3MBTL1 | |
| SCHEMBL209856 | 0.92 | HRH3 (0.44) | KMT2AHPGDALDH1A1HRH3L3MBTL1 | |
| SCHEMBL209857 | 0.92 | HRH3 (0.44) | KMT2AHPGDALDH1A1HRH3L3MBTL1 | |
| SCHEMBL211080 | 0.92 | PDE5A (0.48) | BMPR1BBMPR1AACVRL1ACVR1PDE5A | |
| Hydrochloric Acid SCHEMBL207291 | 0.91 | PDE5A (0.47) | BMPR1BBMPR1AACVRL1ACVR1PDE5A | |
| SCHEMBL209739 | 0.90 | BMPR1B (0.35) | BMPR1BBMPR1AACVRL1ACVR1PDE5A | |
| SCHEMBL209350 | 0.90 | BMPR1B (0.35) | BMPR1BBMPR1AACVRL1ACVR1PDE5A | |
| SCHEMBL209348 | 0.90 | BMPR1B (0.35) | BMPR1BBMPR1AACVRL1ACVR1PDE5A | |
| SCHEMBL209349 | 0.90 | BMPR1B (0.35) | BMPR1BBMPR1AACVRL1ACVR1PDE5A | |
| SCHEMBL2722195 | 0.90 | PDE5A (0.35) | BMPR1BBMPR1AACVRL1ACVR1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-B1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2013-08-28 | — | — | EP | disclosed |