BMPR1B

Bone morphogenetic protein receptor type-1B · O00238 · BMPR1B on Sugi Atlas →

43,355 patent compounds predicted against BMPR1B, 32,571 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Vandetanib (SCHEMBL9044)	1.00	1/20
Saracatinib (SCHEMBL41547)	1.00	1/20
Canertinib (SCHEMBL54837)	1.00	1/20
Quizartinib (SCHEMBL72923)	1.00	1/20
Ruxolitinib (SCHEMBL99225)	1.00	1/20
Ruxolitinib (SCHEMBL101279)	1.00	1/20
Plx-4720 (SCHEMBL133733)	1.00	1/20
Quizartinib (SCHEMBL74121)	0.99	1/20
Dasatinib Anhydrous (SCHEMBL8226)	0.98	1/20
SCHEMBL99245	0.98	1/20
SCHEMBL99371	0.98	1/20
SCHEMBL103135	0.98	1/20
SCHEMBL73633	0.93	1/20
SCHEMBL98692	0.92	1/20
SCHEMBL72924	0.91	1/20
Hydrochloric Acid (SCHEMBL74122)	0.90	1/20
SCHEMBL73035	0.88	1/20
SCHEMBL73476	0.88	1/20
SCHEMBL74273	0.87	1/20
Hydrochloric Acid (SCHEMBL73806)	0.87	1/20

Clinical trials — most relevant to BMPR1B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Vitamin D and Carboxy PTH Fragments in Coronary Calcification	PHASE4	WITHDRAWN
Socket Augmentation Using Atorvastatin With Or Without PRGF (Clinical and Histomorphometric Study)	PHASE4	COMPLETED
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor	PHASE1/PHASE2	COMPLETED
The Use of Adhesion Molecule Loaded Hydrogel With Minimally Invasive Surgical Technique in Treatment of Periodontal Intrabony Defect	PHASE1/PHASE2	COMPLETED
Pharmacokinetics, Safety and Efficacy of BIA 5-1058 in PAH (Zamicastat)	PHASE2	COMPLETED
Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer	PHASE2	COMPLETED
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy	PHASE1	COMPLETED
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
Effect of BMPR-2 Gene Mutations on Hemodynamic Response by Iloprost Inhalation in Pulmonary Arterial Hypertension	nan	COMPLETED
Genetic and Environmental Characteristics of Primary Pulmonary Hypertension	nan	COMPLETED
StratosPHere (Non-interventional Study)	nan	COMPLETED
Short-term Impact of Cyplexinol® on Self-reported Joint Pain	nan	COMPLETED
Role of Novel Biomarkers Associated With In-stent Restenosis After Percutaneous Coronary Intervention	nan	UNKNOWN
Screening of Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers	nan	COMPLETED
Genes-in-Action - Hepcidin Regulation of Iron Supplementation	nan	COMPLETED
Assessment of the TGF-beta Pathway and Micro-RNA in Pediatric Pulmonary Arterial Hypertension	nan	UNKNOWN
BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial Hypertension	nan	COMPLETED
Early Regenerative Intervention for Post-Traumatic Osteoarthritis	nan	UNKNOWN
Gremlin-1 and Wagner Classification: Potential Biomarker for Amputation in Diabetic Foot Patients	nan	COMPLETED
National Cohort Study of Idiopathic and Heritable Pulmonary Arterial Hypertension	nan	UNKNOWN
Exhaled Breath Olfactory Signature of Pulmonary Arterial Hypertension	nan	COMPLETED
AO CSH Mainstream Study on Cervical Spine Degeneration	nan	NOT_YET_RECRUITING
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals	nan	RECRUITING
Therapeutic Irrigation Procedures to Treat Apical Periodontitis	nan	COMPLETED
Induce XT™ Bone Graft in Foot and Ankle Fusion	nan	ENROLLING_BY_INVITATION
TranspulmonarY Estrogen Gradient and Estrogen Receptors (TYEGER) in PAH	nan	WITHDRAWN
Transcription Factor Runx2 in Necrotic Femoral Head Tissue	nan	COMPLETED
Osteoprosis in Type 2 Diabetic Patients- a Cohort Study	nan	UNKNOWN
Immediate Implants in Maxillary Premolar Region Using Xenograft vs Allograft	nan	UNKNOWN
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a BMPR1B binder may also engage these)

Protein	Name	Similarity
Q05438	—	1.000	Q05438 →
Q78EA7	—	1.000	Q78EA7 →
P80202	—	1.000	P80202 →
Q61271	—	1.000	Q61271 →
P36898	—	1.000	P36898 →
Q64729	—	1.000	Q64729 →
P80204	—	1.000	P80204 →
P36895	—	1.000	P36895 →
Q90ZK6	—	1.000	Q90ZK6 →
Q28041	—	1.000	Q28041 →
P70539	—	1.000	P70539 →
P37172	—	1.000	P37172 →
Q5CD18	—	0.999	Q5CD18 →
O46680	—	0.999	O46680 →
P80201	—	0.999	P80201 →
P80203	—	0.997	P80203 →
Q8NER5	—	0.995	Q8NER5 →
TGFBR1	TGF-beta receptor type-1	0.995	landscape →
BMPR1A	Bone morphogenetic protein receptor type-1A	0.995	landscape →
Q24468	—	0.995	Q24468 →
Q61288	—	0.994	Q61288 →
Q8K348	—	0.994	Q8K348 →
ACVR1B	Activin receptor type-1B	0.994	landscape →
Q09488	—	0.992	Q09488 →
ACVR1	Activin receptor type-1	0.990	landscape →
EPHA6	Ephrin type-A receptor 6	0.990	landscape →
EPHA5	Ephrin type-A receptor 5	0.989	landscape →
Q5RAN0	—	0.989	Q5RAN0 →
Q60629	—	0.988	Q60629 →
P54757	—	0.988	P54757 →