Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14723485 | 0.88 | YTHDC1 (0.42) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL14723472 | 0.88 | CYP2C19 (0.39) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL14722645 | 0.83 | CYP2C19 (0.39) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL14722928 | 0.81 | CYP2C19 (0.43) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL14723427 | 0.80 | HTR2C (0.37) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL18309163 | 0.79 | CYP2C19 (0.42) | CYP2C19YTHDC1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL14723191 | 0.79 | CYP2C19 (0.39) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL14723246 | 0.79 | CYP4F2 (0.38) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL15209028 | 0.78 | CYP2C19 (0.41) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA | |
| SCHEMBL14722763 | 0.77 | CYP2C19 (0.39) | CYP2C19YTHDC1CYP4F2CYP4A11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637537-B2 | Serine/threonine kinase inhibitors | GENENTECH, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130225620-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225620-A1 | SERINE/THREONINE KINASE INHIBITORS | PAK1, AKT1, RB1 | CYP2C19 4851/4885YTHDC1 4494/4885CYP4F2 4881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.