Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR9 | P51686 | 7/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | UQCRB | P14927 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15243799 | 0.90 | ALDH1A1 (0.47) | ALDH1A1POLBCCR9GLO1KDM4E | |
| SCHEMBL15218513 | 0.84 | ALDH1A1 (0.48) | ALDH1A1POLBCCR9GLO1KDM4E | |
| SCHEMBL15218527 | 0.84 | ALDH1A1 (0.46) | ALDH1A1POLBCCR9GLO1KDM4E | |
| SCHEMBL15220235 | 0.83 | ALDH1A1 (0.45) | ALDH1A1POLBCCR9KDM4ELMNA | |
| SCHEMBL15218525 | 0.82 | ALDH1A1 (0.50) | ALDH1A1POLBCCR9GLO1KDM4E | |
| SCHEMBL15218553 | 0.81 | PSD (0.52) | ALDH1A1POLBCCR9KDM4ELMNA | |
| SCHEMBL17663439 | 0.80 | ALDH1A1 (0.44) | ALDH1A1POLBCCR9KDM4ELMNA | |
| SCHEMBL15220245 | 0.80 | ALDH1A1 (0.44) | ALDH1A1POLBCCR9KDM4ELMNA | |
| SCHEMBL15218514 | 0.80 | ALDH1A1 (0.48) | ALDH1A1POLBCCR9GLO1KDM4E | |
| SCHEMBL15209654 | 0.80 | ALDH1A1 (0.50) | ALDH1A1POLBCCR9GLO1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021202731-A1 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE USING CCR9 INHIBITOR AND ANTI-IL-23 BLOCKING ANTIBODIES | CHEMOCENTRYX, INC. (US) | 2021-10-07 | — | — | WO | disclosed |
| US-20200197386-A1 | Aza-Aryl 1H-Pyrazol-yl Benzene Sulfonamides | CHEMOCENTRYX INC (US) | 2020-06-25 | — | — | US | disclosed |
| US-10596163-B2 | Aza-aryl 1H-pyrazol-1-yl benzene sulfonamides | CHEMOCENTRYX, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20150073017-A1 | AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES | CHEMOCENTRYX, INC. | 2015-03-12 | — | — | US | disclosed |
| US-8916601-B2 | Aza-aryl 1H-pyrazol-1-YL benzene sulfonamides | CHEMOCENTRYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916601-B2 | Aza-aryl 1H-pyrazol-1-YL benzene sulfonamides | CHEMOCENTRYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-20130225580-A1 | AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225580-A1 | AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225580-A1 | AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES | CCR9, CCR1, CCR3 | ALDH1A1 1144/4885POLB 3503/4885CCR9 1/4885 |
| US-10596163-B2 | Aza-aryl 1H-pyrazol-1-yl benzene sulfonamides | CCR9, CCR1, CCR3 | ALDH1A1 1144/4885POLB 3503/4885CCR9 1/4885 |
| US-20150073017-A1 | AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES | CCR9, CCR1, CCR3 | ALDH1A1 1144/4885POLB 3503/4885CCR9 1/4885 |
| US-20200197386-A1 | Aza-Aryl 1H-Pyrazol-yl Benzene Sulfonamides | CCR9, CCR1, CCR3 | ALDH1A1 1216/4885POLB 3719/4885CCR9 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.