Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 8/20 | 0.40 |
| ▸ | HTR1D | P28221 | 6/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29386661 | 1.00 | CA2 (0.48) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL29398221 | 1.00 | CA2 (0.48) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL4830484 | 1.00 | CA2 (0.48) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL781788 | 1.00 | CA2 (0.48) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| Fluoride SCHEMBL27841384 | 0.98 | CA2 (0.47) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL6028552 | 0.81 | CA2 (0.41) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL30513665 | 0.81 | CA2 (0.41) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL1568046 | 0.81 | CA2 (0.41) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL1568271 | 0.81 | CA2 (0.41) | CA2HTR1AHTR1DSSTR4SIGMAR1 | |
| SCHEMBL6209606 | 0.81 | MAOB (0.41) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817299-B1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LTD (IN) | 2019-06-12 | — | — | EP | disclosed |
| EP-2817299-B1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LTD (IN) | 2019-06-12 | — | — | EP | disclosed |
| US-9987249-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2018-06-05 | — | — | US | disclosed |
| US-9987249-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2018-06-05 | — | — | US | disclosed |
| US-9987249-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2018-06-05 | — | — | US | disclosed |
| US-20170209410-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2017-07-27 | — | — | US | disclosed |
| US-20170209410-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2017-07-27 | — | — | US | disclosed |
| US-20170209410-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2017-07-27 | — | — | US | disclosed |
| US-9598391-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-03-21 | — | — | US | disclosed |
| US-9598391-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-03-21 | — | — | US | disclosed |
| US-20150368222-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-12-24 | — | — | US | disclosed |
| US-20150368222-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-12-24 | — | — | US | disclosed |
| US-9163001-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2015-10-20 | — | — | US | disclosed |
| US-9163001-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2015-10-20 | — | — | US | disclosed |
| US-9163001-B2 | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2015-10-20 | — | — | US | disclosed |
| CN-104350047-A | Substituted chroman compounds as calcium sensing receptor modulators | LUPIN LTD | 2015-02-11 | — | — | CN | disclosed |
| US-20150038546-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-02-05 | — | — | US | disclosed |
| US-20150038546-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-02-05 | — | — | US | disclosed |
| US-20150038546-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-02-05 | — | — | US | disclosed |
| WO-2013124828-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2013-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368222-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, CALCR | CA2 24/4885HTR1A 153/4885HTR1D 257/4885 |
| US-20170209410-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, CALCR | CA2 24/4885HTR1A 153/4885HTR1D 257/4885 |
| US-20150038546-A1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, CALCR | CA2 24/4885HTR1A 153/4885HTR1D 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.