Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.39 |
| ▸ | JAK3 | P52333 | 8/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982764 | 0.85 | JAK2 (0.40) | JAK2JAK3PTK2CCNCCDK8 | |
| SCHEMBL19983050 | 0.85 | JAK2 (0.42) | JAK2JAK3PTK2FLT1FLT4 | |
| SCHEMBL15210501 | 0.84 | JAK2 (0.41) | JAK2JAK3PTK2CCNCCDK8 | |
| SCHEMBL19502 | 0.84 | JAK2 (0.41) | JAK2JAK3PTK2CCNCCDK8 | |
| SCHEMBL16394499 | 0.83 | JAK2 (0.47) | JAK2JAK3PTK2CCNCCDK8 | |
| SCHEMBL20350 | 0.82 | JAK2 (0.43) | JAK2JAK3PTK2ZAP70SYK | |
| SCHEMBL15210458 | 0.81 | JAK2 (0.55) | JAK2JAK3PTK2 | |
| SCHEMBL15210803 | 0.80 | JAK3 (0.42) | JAK2JAK3PTK2CCNCCDK8 | |
| SCHEMBL15210398 | 0.80 | JAK2 (0.50) | JAK2JAK3PTK2KDR | |
| SCHEMBL19160 | 0.80 | JAK2 (0.42) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013124026-A1 | 8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |