Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.40 |
| ▸ | JAK3 | P52333 | 8/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19502 | 0.86 | JAK2 (0.41) | JAK2PTK2JAK3CCNCCDK8 | |
| SCHEMBL15210501 | 0.86 | JAK2 (0.41) | JAK2PTK2JAK3CCNCCDK8 | |
| SCHEMBL15221237 | 0.85 | JAK2 (0.39) | JAK2PTK2JAK3CCNCCDK8 | |
| SCHEMBL16394499 | 0.85 | JAK2 (0.47) | JAK2PTK2JAK3CCNCCDK8 | |
| SCHEMBL20350 | 0.84 | JAK2 (0.43) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL15210458 | 0.83 | JAK2 (0.55) | JAK2PTK2JAK3 | |
| SCHEMBL15210803 | 0.82 | JAK3 (0.42) | JAK2PTK2JAK3CCNCCDK8 | |
| SCHEMBL19160 | 0.82 | JAK2 (0.42) | JAK2PTK2JAK3 | |
| SCHEMBL15210398 | 0.82 | JAK2 (0.50) | JAK2PTK2JAK3KDR | |
| SCHEMBL24486 | 0.79 | JAK2 (0.42) | JAK2PTK2JAK3ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |