Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.80 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24575916 | 0.85 | EPHX2 (0.83) | EPHX2TDP1RAB9AALDH1A1GAA | |
| SCHEMBL14970807 | 0.85 | EPHX2 (0.82) | EPHX2TDP1RAB9AALDH1A1GAA | |
| SCHEMBL15224222 | 0.82 | EPHX2 (0.72) | EPHX2TDP1CA12CA1CA2 | |
| SCHEMBL15359448 | 0.80 | EPHX2 (0.72) | EPHX2TDP1CA12CA1CA2 | |
| SCHEMBL31556343 | 0.79 | EPHX2 (0.68) | EPHX2TDP1RAB9AALDH1A1GAA | |
| SCHEMBL5116644 | 0.78 | HPGD (0.71) | EPHX2TDP1RAB9AALDH1A1HPGD | |
| SCHEMBL5125065 | 0.78 | EPHX2 (0.71) | EPHX2TDP1RAB9AALDH1A1GAA | |
| SCHEMBL10151326 | 0.77 | CHRM2 (0.73) | EPHX2TDP1CA12CA1CA2 | |
| SCHEMBL23012354 | 0.77 | EPHX2 (0.60) | EPHX2TDP1RAB9AALDH1A1GAA | |
| SCHEMBL3524135 | 0.76 | EPHX2 (0.63) | EPHX2TDP1RAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439202-B1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | SALVAT LAB SA (ES) | 2016-04-20 | — | — | EP | disclosed |
| US-8524894-B2 | Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1 | LABORATORIOS SALVAT, S.A. (ES) | 2013-09-03 | — | — | US | disclosed |