Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.47 |
| ▸ | KDR | P35968 | 13/20 | 0.47 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1741956 | 0.87 | MET (0.45) | METKDRAXLKITFLT3 | |
| SCHEMBL1741301 | 0.85 | MET (0.45) | METKDRAXLKITFLT3 | |
| SCHEMBL1743552 | 0.82 | MET (0.55) | METKDRAXLKITFLT3 | |
| SCHEMBL1742660 | 0.82 | MET (0.44) | METKDRAXLKITFLT3 | |
| SCHEMBL2838272 | 0.80 | MET (0.51) | METKDRAXLKITFLT3 | |
| SCHEMBL1743562 | 0.79 | MET (0.45) | METKDRAXLKITFLT3 | |
| SCHEMBL1742647 | 0.79 | MET (0.55) | METKDRAXLKITFLT3 | |
| SCHEMBL1741332 | 0.79 | KDM4E (0.48) | METKDRAXLKITFLT3 | |
| SCHEMBL1741960 | 0.78 | MET (0.51) | METKDRAXLKITFLT3 | |
| SCHEMBL1742091 | 0.77 | MET (0.44) | METKDRAXLKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387575-B1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ANVYL LLC (US) | 2013-09-04 | — | — | EP | disclosed |